For patients with malignant pancreatic cancer combined with vascular invasion, radical pancreaticoduodenectomy with vascular resection and anastomosis is the treatment of choice. Because this procedure is difficult to manage and with high risks, it is a great challenge to surgeons. A 50year old patient with pancreatic head cancer whose portal vein and superior mesenteric vein were involved received radical pancreaticoduodenectomy in the Second Affiliated Hospital of Harbin Medical University. In the surgery, the tumor and its surrounding tissues were dissected, and then the portal vein and splenic vein were reconstructed. The patient was discharged at the 10th day after the surgery with favorable prognosis.